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Bone marrow suppressionincluding the idiosyncratic type of irreversible and fatal aplastic anaemia that is recognized to occur with systemic therapyhas been reported in association with topical administration of chloramphenicol.

Gram-negativeHemophilus influenzaeMcatarrhalisNmeningitidesEcoliPmirabilisSalmonella sppShigella sppStenotrophomonas maltophilia.

Bone marrow hypoplasiaincluding aplastic anaemia and deathhas been reported following topical use of chloramphenicolWhilst the hazard is a rare oneit should be borne in mind when assessing the benefits expected from the use of the compound.

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