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A lower dose should be considered for patients with a history of hepatic impairmentThere is no therapeutic experience in patients with severe hepatic impairmentThereforelosartan is contraindicated in patients with severe hepatic impairmentsee sections 4.3 and 4.4

There is evidence that the concomitant use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren increases the risk of hypotensionhyperkalaemiaand decreased renal functionincluding acute renal failureDual blockade of RAAS through the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is therefore not recommendedsee sections 4.5 and 5.1

When pregnancy is detecteddiscontinue COZAAR as soon as possibleDrugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetussee WARNINGS AND PRECAUTIONS

As with any antihypertensive agentsexcessive blood pressure decrease in patients with ischaemic cardiovascular and cerebrovascular disease could result in a myocardial infarction or stroke.

Losartan is used to treat high blood pressurehypertensionand to help protect the kidneys from damage due to diabetesIt is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heartLowering high blood pressure helps prevent strokesheart attacksand kidney problemsLosartan belongs to a class of drugs called angiotensin receptor blockersARBsIt works by relaxing blood vessels so that blood can flow more easily.

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