Specifically, zofran can increase the qt interval, leading to an abnormal heart condition known as torsades de pointes or twisting of the points.
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The most common adverse reactions reported in 4 trials in adults for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapyprimarily cyclophosphamide-based regimensare shown in Table 3.
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The most common adverse reactionsgreater than or equal to 2reported in patients receiving ZOFRAN and concurrent radiotherapy were similar to those reported in patients receiving ZOFRAN and concurrent chemotherapy and were headacheconstipationand diarrhea.
Ondansetron hydrochloride dihydrate is a white to off-white powder that is soluble in water and normal saline.
Keep the tablet in its blister pack until you are ready to take the medicineOpen the package and peel back the foil from the tablet blisterDo not push a tablet through the foil or you may damage the tabletUsing dry handsremove the tablet and place it in your mouthIt will begin to dissolve right awayDo not swallow the tablet wholeAllow it to dissolve in your mouth without chewingSwallow several times as the tablet dissolvesIf desiredyou may drink liquid to help swallow the dissolved tablet.
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zofran should be administered immediately before chemotherapy as a single intravenous dose of 0.