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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofbreathing problemssuch as asthmachronic obstructive pulmonary disease-COPDsleep apneablood/immune system problemssuch as bone marrow depressionhigh pressure in the eyeglaucomaheart diseasesuch as irregular heartbeathigh blood pressureliver diseasecertain brain disorderssuch as neuroleptic malignant syndromeReye’s syndromeseizuresstomach/intestine problemssuch as blockageulceroveractive thyroidhyperthyroidismdifficulty urinatingfor exampledue to enlarged prostate

Tell your doctor right away if you have any serious side effectsincludingfaintingslow heartbeatmental/mood changessuch as hallucinationsnervousnessirritabilityrestlessnessconfusionunusual/uncontrolled movementssuch as fixed upward stareneck twistingtongue movementsshakingtremordifficulty urinatingeasy bleeding/bruisingsigns of infectionsuch as feverpersistent sore throatsevere stomach/abdominal painpersistent nausea/vomitingyellowing eyes/skin.

Promethazine hydrochloride tablets are contraindicated for use in pediatric patients less than two years of age.

Allergic rhinitisrunny nose and watery eyesAllergic conjunctivitisredwatery eyesAllergic skin reactionsrashhivesAllergic reactions to blood or plasma products.

Signs and symptoms of overdosage with promethazine HClpromethazine hydrochloriderange from mild depression of the central nervous system and cardiovascular system to profound hypotensionrespiratory depressionunconsciousnessand sudden deathOther reported reactions include hyperreflexiahypertoniaataxiaathetosisand extensor-plantar reflexesBabinski reflex

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