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Rocaltrolcalcitriolis the most potent metabolite of vitamin D availableThe administration of Rocaltrolcalcitriolto patients in excess of their daily requirements can cause hypercalcemiahypercalciuriaand hyperphosphatemiaThereforepharmacologic doses of vitamin D and its derivatives should be withheld during Rocaltrolcalcitrioltreatment to avoid possible additive effects and hypercalcemiaIf treatment is switched from ergocalciferolvitamin D 2to calcitriolit may take several months for the ergocalciferol level in the blood to return to the baseline valuesee OVERDOSAGE

Malabsorption is occasionally noted in patients with hypoparathyroidismhencelarger doses of Rocaltrolcalcitriolmay be needed.

Patients with normal renal function who are taking Rocaltrol should avoid dehydrationAdequate fluid intake should be maintained.

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