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The efficacy of sinemet sr was established in a randomized, double-blind,double-dummy, active-controlled, parallel group, 12-week study study1 in patients with advanced parkinson s disease who were levodopa-responsiveand had persistent motor fluctuations while on treatment with oralimmediate-release carbidopa-levodopa and other parkinson s diseasemedications.

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Caution should be exercised when the following drugs are administered concomitantly with SINEMET.

There are no adequate or well-controlled studies in pregnant womenIt has been reported from individual cases that levodopa crosses the human placental barrierenters the fetusand is metabolizedCarbidopa concentrations in fetal tissue appeared to be minimalUse of SINEMET in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child.

Use of SINEMET with dopamine-depleting agentse.greserpine and Medrol dose pack over the counter tetrabenazineor other drugs known to deplete monoamine stores is not recommended.

SINEMET is contraindicated in patients with known hypersensitivity to any component of this drugand in patients with narrow-angle glaucoma.

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