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Patients with a known allergic hypersensitivity to methotrexate or any of the other ingredients should not receive methotrexate.

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Information about Methotrexate.

Methotrexate has caused birth defects and death in unborn babiesWomen must avoid becoming pregnant while taking this medicationPregnant women who have psoriasis or rheumatoid arthritis must not use methotrexateSee also Precautions section

Methotrexate has rarely caused serioussometimes fatalside effectsThereforethis medication should be used only to treat cancer or severe diseases caused by an overactive immune systemsuch as psoriasisrheumatoid arthritis

For the treatment of psoriasis or rheumatoid arthritistake this medication by mouth as directed by your doctorusually once a weekIt may take up to several months before you get the full benefit of this drug.

This medication may lower your ability to fight infectionsThis may make you more likely to get a seriousrarely fatalinfection or make any infection you have worseTell your doctor right away if you have any signs of infectionsuch as feverchillspersistent sore throatcough

If the patient is vomiting or unable to tolerate oral medicationleucovorin should be added to this regimen at the same dose and schedule as the methotrexate.

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abortion, foetal death, and or congenital anomalies have occurred in pregnant women receiving methotrexate, especially during the first trimester of pregnancy.

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