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If rizatriptan is administered according to the maximum dosage regimenno drug accumulation in the plasma occurs from day to day.

Rizatriptan is a headache medicine that narrows the blood vessels around the brainRizatriptan also reduces substances in the body that can trigger headache painnauseasensitivity to light and soundand other migraine symptoms.

Ergotamineergot derivativesincluding methysergideother 5-HT 1B/1D receptor agonistsDue to an additive effectthe concomitant use of rizatriptan and ergotamineergot derivativesincluding methysergideor other 5-HT 1B/1D receptor agonistse.gsumatriptanzolmitriptannaratriptanincrease the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contra-indicatedsee section 4.3

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