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The adequacy of therapy is determined by periodic assessment of appropriate laboratory tests and clinical evaluationThe choice of laboratory tests depends on various factors including the etiology of the underlying thyroid diseasethe presence of concomitant medical conditionsincluding pregnancyand the use of concomitant medicationssee DRUG INTERACTIONS and DrugLaboratory Test InteractionsPersistent clinical and laboratory evidence of hypothyroidism despite an apparent adequate replacement dose of SYNTHROID may be evidence of inadequate absorptionpoor compliancedrug interactionsor decreased T 4 potency of the drug product.

Levothyroxine doses are based on weight in childrenYour dose needs may change if you gain or lose weight.

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