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Unexpected bleeding or bleeding that lasts a long time blood in your urinepinkred or brown urinered or black stoolslooks like tarbruises that happen without a known cause or get larger cough up blood or blood clots vomit blood or your vomit looks like coffee grounds.

Clopidogrel is metabolized to its active metabolite in part by CYP2C19Concomitant use of drugs that inhibit the activity of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibitionsee WARNINGS AND PRECAUTIONS

The observed risk of bleeding events with Plavix plus aspirin versus placebo plus aspirin by age category is provided in Table 1 and Table 2 for the CURE and COMMIT trialsrespectivelysee ADVERSE REACTIONSNo dosage adjustment is necessary in elderly patients.

The trial’s primary outcome was the time to first occurrence of new ischemic strokefatal or notnew myocardial infarctionfatal or notor other vascular deathDeaths not easily attributable to nonvascular causes were all classified as vascular.

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