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Undesirable alterations in lipids have been observed in patients treated with atypical antipsychoticsincluding ClozarilClinical monitoringincluding baseline and periodic follow-up lipid evaluations in patients using clozapineis recommended.

Analysis of safety databases suggests that the use of Clozaril is associated with an increased risk of myocarditis especially duringbut not limited tothe first two months of treatmentSome cases of myocarditis have been fatalPericarditis/pericardial effusion and cardiomyopathy have also been reported in association with Clozaril usethese reports also include fatalitiesMyocarditis or cardiomyopathy should be suspected in patients who experience persistent tachycardia at restespecially in the first two months of treatmentand/or palpitationsarrhythmiaschest pain and other signs and symptoms of heart failuree.gunexplained fatiguedyspnoeatachypnoeaor symptoms that mimic myocardial infarctionOther symptoms which may be present in addition to the above include flu-like symptomsIf myocarditis or cardiomyopathy is suspectedClozaril treatment should be promptly stopped and the patient immediately referred to a cardiologist.

This medication is used to treat certain mental/mood disordersschizophreniaschizoaffective disordersClozapine is a psychiatric medicationanti-psychotic typethat works by helping to restore the balance of certain natural substancesneurotransmittersin the brain.

Clozaril can have long lasting effects on your bodyYou may need frequent medical tests for a short time after you stop using this medicine.

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