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If rifabutin is used concomitantly, rifabutin dose should be reduced because of inhibition of rifabutin metabolism; with concomitant indinavir or nelfinavir use, reduce rifabutin dose by 50 .

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In hot weather when dancing or exercising if you have diarrhea if you have been vomiting.

If you miss a dose by lessthan 2 hourstake the missed dose as soon as you remember itHoweverif you miss a dose by more than 2 hoursskip the missed dose and continue your regular dosing scheduleDo not take a double dose to make up for a missed one.

Indinavir belongs to a group or class of drugs called protease inhibitorsIndinavir interferes with an enzyme called proteasewhich is used by HIV-infected cells to make new virusesSince indinavir inhibitsor reduces the activity of this enzymethis drug causes HIV-infected cells to produce fewer viruses.

Urogenital Systemnephrolithiasis/urolithiasisin some cases resulting in renal insufficiency or acute renal failurepyelonephritis with or without bacteremiasee WARNINGSinterstitial nephritis sometimes with indinavir crystal depositsin some patientsthe interstitial nephritis did not resolve following discontinuation of CRIXIVANrenal insufficiencyrenal failureleukocyturiasee PRECAUTIONScrystalluriadysuria.

To explain how indinavir workswe needto first tell you some information about HIVWhen HIV infects a cellit takes control of that cellHIV then forces the cell to make many more copies of the virusTo make these copiesthe cell uses proteins called enzymesWhen the activity of these enzymes is reduced the production of HIV slows.

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