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Do not use mirtazapine if you have used an MAO inhibitor within the past 14 daysSeriouslife-threatening side effects can occur if you take mirtazapine before the MAO inhibitor has cleared from your body.

Do not dispose of medications in wastewatere.gdown the sink or in the toiletor in household garbageAsk your pharmacist how to dispose of medications that are no longer needed or have expired.

Caution should be exercised when coadministering mirtazapine with potent CYP3A4 inhibitorsHIV protease inhibitorsazole antifungalserythromycinor nefazodone.

A major depressive episode may be the initial presentation of bipolar disorderIt is generally believedthough not established in controlled trialsthat treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorderWhether any of the symptoms described above represent such a conversion is unknownHoweverprior to initiating treatment with an antidepressantpatients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disordersuch screening should include a detailed psychiatric historyincluding a family history of suicidebipolar disorderand depressionIt should be noted that REMERONmirtazapineTablets are not approved for use in treating bipolar depression.

Do not stop using mirtazapine suddenlyor you could have unpleasant withdrawal symptomsAsk your doctor how to avoid withdrawal symptoms when you stop using mirtazapine.

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